#Free clinical trials for blepharospasms skin
For this test, electrodes (small metal disks) are filled with a conductive gel and taped to the skin of the face. Surface EMG is done during TMS to measure the electrical activity of muscles. Subjects receive 60 pulses per minute over 15 minutes. Repetitive TMS involves repeated magnetic pulses delivered in short bursts of impulses. During the stimulation, subjects may be asked to tense certain muscles slightly or perform other simple actions. There may be a twitch in muscles of the face, arm or leg. The subject hears a click and may feel a pulling sensation on the skin under the coil. A brief electrical current is passed through the coil, creating a magnetic pulse that stimulates the brain. Participants undergo transcranial magnetic stimulation (TMS) and electromyography (EMG) in two 4-hour sessions, separated by 1 to 7 days.Ī wire coil is held on the subject s scalp. People with blepharospasm also have a physical examination and blepharospasm rating. All candidates are screened with a medical history. Healthy volunteers and people with blepharospasm who are 18 years of age and older may be eligible for this study. The study will compare brain activity in healthy volunteers and in people with blepharospasm to find differences in the brain that may lead to better treatments for dystonia. This study will examine the role of certain areas of the brain in blepharospasm, a type of dystonia (abnormality of movement and muscle tone) that causes unwanted or uncontrollable blinking or closing of the eyelids. Why Should I Register and Submit Results?.